Clinical outcome of single intra articular injection of triamcinolone acetonide depot preparation on knee osteoarthritis

Abstract

Oral pharmacological agents are not effective for long term and have many side effects if used for longer period of time. Intraarticular injection of hyaluronic acid injections and other biological agents like bone marrow aspiration concentrate are of still questionable value. Hence till today intraarticular steroid are routinely used in practise in the world all over. Hence we decided to carry out a retrospective review study to assess if the steroids were effective after 24 weeks. A retrospective review study was performed at MIMER Medical College and BSTR Hospital from Jan 2008 to December 2017. Patients with osteoarthritis of knee joint aged 50 years to 80 years of both sexes were included in the study. One thousand and twelve patients were included. We collected data of patients from hospital records. 40 mg of triamcinolone acetonide which is a long acting depot preparation of triamcinolone (potent synthetic corticosteroid which is having selective glucocorticoid activity) was used for intraarticular injection into knee joint under strict antiseptic and aseptic precautions. There was a statistically significant decrease in the initial VAS and WOMAC scores at 3 weeks,12weeks and 24 weeks after intraarticular injection (p