articleTop 1% cited

Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder

The British Journal of Psychiatry · 1998 · Vol. 173(S35) · pp. 26–37

S Saxena✉(Neurobehavioral Systems)Arthur L. Brody(Neurobehavioral Systems)Jeffrey M. Schwartz(Neurobehavioral Systems)L.R. Baxter(University of Alabama at Birmingham)

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Abstract

OCD symptoms are mediated by hyperactivity in orbitofrontal-subcortical circuits, perhaps due to an imbalance of tone between direct and indirect striato-pallidal pathways. We present a model which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and suggest a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity.

Obsessive-Compulsive Spectrum Disorders Neurotransmitter Receptor Influence on Behavior Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeuroimagingNeurosciencePsychologyOrbitofrontal cortexBasal gangliaThalamusFunctional neuroimagingNeuroanatomyAnterior cingulate cortexCaudate nucleus

MeSH terms

Brain DiseasesCerebrovascular CirculationCognition DisordersHumansMagnetic Resonance ImagingObsessive-Compulsive DisorderTomography, Emission-ComputedTomography, Emission-Computed, Single-Photon

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833

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31.18

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Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited