Possible mechanisms of anti-inflammatory and analgesic effects of the aqueous extracts of Ceiba pentandra Gaertn (Bombacaceae) and Chromolaena odorata L (King and Robinson) (Astéraceae) in rat

Abstract

The aim of this study was to investigate the probable mechanisms of anti-inflammatory and analgesic effects of the aqueous extracts of C. pentandra and C. odorata. The possible mechanisms of inflammatory effect were investigated in rat by the local administration into the plantar aponeurosis of the histamine, serotonin and the arachidonic acid. The results obtained show that the aqueous extracts of C. pentandra (400 and 800 mg/kg) and of C. odorata (400 and 800 mg/kg) inhibit the histamine, serotonin and the arachidonic acid inflammation. This suggests that these two aqueous extracts could interfere with their inflammatory mechanisms. The probable mechanisms of analgesic effect were investigated in rat by the localadministration into the plantar aponeurosis of formaldehyde solution in the naloxone presence. The results obtained showed an inhibiting pain of the two extracts at the doses used on the two phases (neurogenic response and inflammatory response) of pain in spite of the preliminary administration of naloxone. This result suggests that these two extracts could act by not opioid mechanism.