Antimicrobial, membrane stabilizing and thrombolytic activities of ethanolic extract of Curcuma zedoaria Rosc. Rhizome

Abstract

The present study was undertaken to evaluate the inherent anti-inflammatory, thrombolytic and antimicrobial potential of ethanolic extract of the rhizome of Curcuma zedoaria (EECZR). In vitro anti-inflammatory activity was uncovered by using human erythrocyte membrane stabilization and egg albumin denaturation method. In vitro thrombolytic activity was investigated and compared with streptokinase. Antimicrobial activity was evaluated by using disc diffusion method. EECZR dose dependently showed a potent anti-inflammatory activity. In addition, thrombolytic activity was found to be 28.46±4.16%, 9.67±6.37 and 65.96±4.25% for EECZR, normal saline and streptokinase (a positive control) respectively. This extract also showed potent antibacterial activity against eight pathogenic bacteria and produced inhibition zone ranging from 10 to 15 mm. The minimum inhibitory concentrations (MICs) of the ethanol extract was found to be in the range of 64 ~ 256 I¼g/ml. Our results suggest that ethanol extract of Curcuma zedoaria rhizome has strong anti-inflammatory, thrombolytic and antimicrobial activities.