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Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Biological Psychiatry · 2018 · Vol. 84(9) · pp. 644–654

Theo G.M. van Erp✉(University of California, Irvine)Esther Walton(Georgia State University)Derrek P. Hibar(University of Southern California)Lianne Schmaal(Amsterdam UMC Location Vrije Universiteit Amsterdam)Wenhao Jiang(Georgia State University)David C. Glahn(Hartford Financial Services (United States))Godfrey D. Pearlson(Hartford Financial Services (United States))Nailin Yao(Hartford Financial Services (United States))Masaki Fukunaga(National Institute for Physiological Sciences)Ryota Hashimoto(The University of Osaka)Naohiro Okada(The University of Tokyo)Hidenaga Yamamori(The University of Osaka)Juan Bustillo(University of New Mexico)Vincent P. Clark(University of New Mexico)Ingrid Agartz(Karolinska Institutet)Bryon A. Mueller(University of Minnesota)Wiepke Cahn(University Medical Center Utrecht)Sonja M. C. de Zwarte(University Medical Center Utrecht)Hilleke E. Hulshoff Pol(University Medical Center Utrecht)René S. Kahn(University Medical Center Utrecht)Roel A. Ophoff(University of California, Los Angeles)Neeltje E.M. van Haren(Erasmus University Rotterdam)Ole A. Andreassen(University of Oslo)Anders M. Dale(University of California San Diego)Nhat Trung Doan(University of Oslo)Tiril P. Gurholt(University of Oslo)Cecilie B. Hartberg(University of Oslo)Unn K. Haukvik(Oslo University Hospital)Kjetil Nordbø Jørgensen(University of Oslo)Trine Vik Lagerberg(Oslo University Hospital)Ingrid Melle(University of Oslo)Lars T. Westlye(Oslo University Hospital)Oliver Gruber(University Hospital Heidelberg)Bernd Kraemer(University Hospital Heidelberg)Anja Richter(Heidelberg University)David Zilles‐Wegner(University of Göttingen)Vince D. Calhoun(Mind Research Network)Benedicto Crespo‐Facorro(Instituto de Investigación Marqués de Valdecilla)Roberto Roiz‐Santiáñez(Marqués de Valdecilla University Hospital)Diana Tordesillas‐Gutiérrez(Centro de Investigación Biomédica en Red de Salud Mental)Carmel Loughland(Hunter Medical Research Institute)Vaughan J. Carr(Monash University)Stanley V. Catts(The University of Queensland)Vanessa Cropley(The University of Melbourne)Janice M. Fullerton(UNSW Sydney)Melissa J. Green(Neuroscience Research Australia)Frans Henskens(Hunter Medical Research Institute)Assen Jablensky(The University of Western Australia)Rhoshel Lenroot(Neuroscience Research Australia)Bryan Mowry(The University of Queensland)Patricia T. Michie(University of Newcastle Australia)Christos Pantelis(The University of Melbourne)Yann Quidé(UNSW Sydney)Ulrich Schall(Hunter Medical Research Institute)Rodney J. Scott(University of Newcastle Australia)Murray J. Cairns(University of Newcastle Australia)Marc L. Seal(Murdoch Children's Research Institute)Paul A. Tooney(Hunter Medical Research Institute)Paul E. Rasser(University of Newcastle Australia)Gavin Cooper(University of Newcastle Australia)Cynthia Shannon Weickert(UNSW Sydney)Thomas W. Weickert(UNSW Sydney)Derek W. Morris(Trinity College Dublin)Elliot Hong(University of Maryland, Baltimore)Peter Kochunov(University of Maryland, Baltimore)Lauren M. Beard(University of Pennsylvania)Raquel E. Gur(University of Pennsylvania)Ruben C. Gur(University of Pennsylvania)Theodore D. Satterthwaite(University of Pennsylvania)Daniel H. Wolf(University of Pennsylvania)Ayşenil Belger(Duke Medical Center)Greg Brown(University of California San Diego)Judith M. Ford(University of California, San Francisco)Fabìo Macciardi(University of California, Irvine)Daniel H. Mathalon(San Francisco VA Medical Center)Daniel S. OʼLeary(University of Iowa)Steven G. Potkin(University of California, Irvine)Adrian Preda(University of California, Irvine)James T. Voyvodic(Duke University Hospital)Kelvin O. Lim(University of Minnesota)Sarah McEwen(University of California, Los Angeles)Fude Yang(Beijing HuiLongGuan Hospital)Yunlong Tan(Beijing HuiLongGuan Hospital)Shuping Tan(Beijing HuiLongGuan Hospital)Zhiren Wang(Beijing HuiLongGuan Hospital)Fengmei Fan(Beijing HuiLongGuan Hospital)Jing Chen(Beijing HuiLongGuan Hospital)Hong Xiang(Chongqing Three Gorges Central Hospital)Shiyou Tang(Chongqing Three Gorges Central Hospital)Hua Guo(Zhumadian Central Hospital)Ping Wan(Zhumadian Central Hospital)Wei DongH. Jeremy Bockholt(Mind Research Network)Stefan Ehrlich(Athinoula A. Martinos Center for Biomedical Imaging)Rick P.F. Wolthusen(Massachusetts General Hospital)Margaret King(Mind Research Network)Jody M. Shoemaker(Mind Research Network)Scott R. Sponheim(Minneapolis VA Health Care System)Lieuwe de Haan(Amsterdam UMC Location University of Amsterdam)Laura Koenders(Amsterdam UMC Location University of Amsterdam)Marise W. J. Machielsen(University of Amsterdam)Thérèse van Amelsvoort(Maastricht University)Dick J. Veltman(Vrije Universiteit Amsterdam)Francesca Assogna(Centro Ricerche Enrico Fermi)Nerisa Banaj(Fondazione Santa Lucia)Pietro De Rossi(Sapienza University of Rome)Mariangela Iorio(Fondazione Santa Lucia)Fabrizio Piras(Fondazione Santa Lucia)Gianfranco Spalletta(Baylor College of Medicine)Peter J. McKenna(Hospital Mare de Déu de la Mercè)Edith Pomarol‐Clotet(Hospital Mare de Déu de la Mercè)Raymond Salvador(Centro de Investigación Biomédica en Red de Salud Mental)Aiden Corvin(Trinity College Dublin)Gary Donohoe(Trinity College Dublin)Sinéad Kelly(Brigham and Women's Hospital)Christopher D. Whelan(University of Southern California)Erin W. Dickie(Centre for Addiction and Mental Health)David Rotenberg(Centre for Addiction and Mental Health)Aristotle N. Voineskos(Centre for Addiction and Mental Health)Simone Ciufolini(King's College London)Joaquim Raduà(King's College London)Paola Dazzan(South London and Maudsley NHS Foundation Trust)Robin Murray(King's College London)Tiago Reis Marques(King's College London)Andrew Simmons(King's College London)Stefan Borgwardt(University of Basel)Laura Egloff(University of Basel)Fabienne Harrisberger(University of Basel)Anita Riecher‐Rössler(University of Basel)Renata Smieskova(University of Basel)Kathryn Alpert(Northwestern University)Lei Wang(Northwestern University)Erik G. Jönsson(University of Oslo)Sanne Koops(University Medical Center Utrecht)Iris E. Sommer(University Medical Center Groningen)Alessandro Bertolino(University of Bari Aldo Moro)Aurora Bonvino(Casa Sollievo della Sofferenza)Annabella Di Giorgio(Casa Sollievo della Sofferenza)Emma Neilson(University of Edinburgh)Andrew R. Mayer(Mind Research Network)Julia M. Stephen(Mind Research Network)Jun Soo Kwon(Seoul National University)Je‐Yeon Yun(Seoul National University)Dara M. Cannon(Ollscoil na Gaillimhe – University of Galway)Colm McDonald(Ollscoil na Gaillimhe – University of Galway)И. С. Лебедева(Mental Health Research Center of Russian Academy of Medical Sciences)A. S. Tomyshev(Mental Health Research Center of Russian Academy of Medical Sciences)Tolibjohn Akhadov(Research Institute of Emergency Childrens Surgery and Traumatology)В. Г. Каледа(Mental Health Research Center of Russian Academy of Medical Sciences)Helena Fatouros‐Bergman(Stockholm County Council)Lena Flyckt(Stockholm County Council)Geraldo F. Busatto(Universidade de São Paulo)Pedro G. P. Rosa(Universidade de São Paulo)Maurício H. Serpa(Universidade de São Paulo)Marcus V. Zanetti(Universidade de São Paulo)Cyril Höschl(National Institute of Mental Health)Antonín Škoch(Institute of Clinical and Experimental Medicine)Filip Španiel(National Institute of Mental Health)David Tomeček(Czech Academy of Sciences, Institute of Computer Science)Saskia P. Hagenaars(University of Edinburgh)Andrew M. McIntosh(University of Edinburgh)Heather C. Whalley(University of Edinburgh)Stephen M. Lawrie(University of Edinburgh)Christian Knöchel(University Hospital Frankfurt)Viola Oertel‐Knöchel(University Hospital Frankfurt)Michael Stäblein(Goethe University Frankfurt)Fleur M. Howells(University of Cape Town)Dan J. Stein(University of Cape Town)Henk Temmingh(Groote Schuur Hospital)Anne Uhlmann(Stellenbosch University)Carlos López‐Jaramillo(Universidad de Antioquia)Danai Dima(City, University of London)Mary McMahon(University of Southern California)Joshua I. Faskowitz(University of Southern California)Boris A. Gutman(Illinois Institute of Technology)Neda Jahanshad(University of Southern California)Paul M. Thompson(University of Southern California)Jessica A. Turner(Georgia State University)Lars Farde(Oslo University Hospital)Lena Flyckt(Karolinska Institutet)Göran EngbergSophie ErhardtHelena Fatouros‐Bergman(Karolinska Institutet)Simon Červenka(King's College London)Lilly SchwielerFredrik PiehlIngrid Agartz(Diakonhjemmet Hospital)Karin CollstePauliina VictorssonAnna Malmqvist(Casa Sollievo della Sofferenza)Mikael HedbergFunda Orhan

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Abstract

The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.

Schizophrenia research and treatment Functional Brain Connectivity Studies Advanced Neuroimaging Techniques and ApplicationsSchizophrenia (object-oriented programming)NeuroimagingTemporal lobeAntipsychoticFrontal lobePsychologyCortex (anatomy)Meta-analysisLateralization of brain functionPsychosis

MeSH terms

AdolescentAdultAgedBrainChildFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedSchizophreniaSeverity of Illness IndexTemporal LobeLinear Models

Funding

U.S. Department of Veterans Affairs
Eli Lilly and Company
Brigham and Women's Hospital
Massachusetts General Hospital
Yale University
University of Southern California
University of Pennsylvania
Northwestern University
University of Minnesota
České Vysoké Učení Technické v Praze
Universität Basel
South London and Maudsley NHS Foundation Trust
National University of Ireland
Hunter New England Local Health District
Children’s Hospital of Wisconsin Research Institute
Neuroscience Research Australia
Murdoch Children's Research Institute
Universitätsmedizin Göttingen
National Institute for Health and Care Research
King's College London
Hunter Medical Research Institute
University of Galway
University of New South Wales
Monash University
Universiteit van Amsterdam
Vrije Universiteit Amsterdam
Universiteit Maastricht
Seoul National University
Technische Universität Dresden
Karolinska Institutet
Akademie Věd České Republiky
Sapienza Università di Roma
Seoul National University Hospital
Stockholms Läns Landsting
Universiteit Stellenbosch
Universitair Medisch Centrum Groningen
Universidad de Antioquia
Universitetet i Oslo
Universidade de São Paulo
Universidad de Cantabria
Centre d'Imagerie BioMédicale
University of Cape Town
Diakonhjemmet
Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi
Centre for Cognitive Ageing and Cognitive Epidemiology
Instituto de Investigación Marqués de Valdecilla
Universitätsklinikum Heidelberg
National Institutes of Health
University of California, Los Angeles
City, University of London
University of North Carolina at Chapel Hill
University of California, San Diego
University of California, San Francisco
Feinberg School of Medicine
University of California, Irvine
Institute of Psychiatry, Psychology and Neuroscience, King’s College London
College of Medicine, Seoul National University
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Medical Research Council
Queensland Brain Institute
National Institute of Mental Health
National Institute of Biomedical Imaging and Bioengineering
Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
School of Medicine, University of California, Irvine
National Institute for Physiological Sciences