Formulation floating tablet of from aqueous extract of Acacia and its evaluation

Abstract

Introduction: Floating tablets prolong the gastric residence time of drugs, improve bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing aqueous extract of acacia as drug was prepared for the treatment of Helicobacter pylori and gastric ulcers. Methods: The aqueous extract of acacia was standardized by TLC. Tablets containing HPMC, Acacia extract, sodium bicarbonate (gas generating agent), talc, and magnesium stearate were prepared using direct compression method. The formulations were evaluated for physical parameters like diameter, thickness, hardness, friability, uniformity of weight, drug content, buoyancy time, dissolution, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in vitro drug release.