article Open Access
Development and validation of RP-HPLC method for simultaneous determination of paraben preservatives in pharmaceutical liquid dosage
Journal of Pharmacognosy and Phytochemistry · 2018 · Vol. 7(2) · pp. 1243–1245
Abstract
A reversed phase HPLC method has been developed that allows the simultaneous estimation of the methyl paraben (MP) and propyl paraben (PP) in pharmaceutical liquid dosage form. The mobile phase was filtered and degassed mixture of buffer (pH 2.0) and acetonitrile (68: 32). The detector wavelength was set at 205 nm and flow rate was 1.0 mL/min. Under these conditions, separation of the two components was achieved in less than 10 min. Validation parameters allow to consider the method adequate. The method was successfully used for estimating both paraben preservatives in pharmaceutical liquid formulation.
Analytical Chemistry and ChromatographyAdvanced Chemical Sensor TechnologiesBiopolymer Synthesis and ApplicationsParabenPreservativeChromatographyChemistryHigh-performance liquid chromatographyDosage formAcetonitrileBioanalysis
Citations
1
FWCI
0.00
field-weighted impact
References
0
Percentile
2%
vs. same field & year
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.