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A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum

Diseases of the Colon & Rectum · 1997 · Vol. 40(2) · pp. 131–139

David M. Hyams✉(Allegheny General Hospital)Eleftherios P. MamounasNicholas J. PetrelliHoward E. RocketteJ JonesH. Samuel WieandMelvin DeutschLawrence WickerhamB. FisherNorman Wolmark

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Abstract

These data do suggest that the preoperative chemotherapy and radiation therapy regimen used are, at least, as safe and tolerable as standard postoperative treatment. There is presently a trend to tumor downstaging and sphincter preservation in the preoperative arm. Whether this arm will have greater or lesser survival and long-term toxicity awaits the completion of this relevant study.

Colorectal Cancer Surgical Treatments Colorectal and Anal Carcinomas Colorectal Cancer Screening and DetectionMedicineSurgeryRadiation therapyRectumRegimenColorectal surgeryChemotherapyRandomizationColorectal cancerRandomized controlled trial

MeSH terms

AdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsLeucovorinFemaleFluorouracilHumansMaleMiddle AgedPostoperative CarePostoperative ComplicationsPreoperative CareRadiotherapy DosageRectal NeoplasmsChemotherapy, AdjuvantRadiotherapy, Adjuvant

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T-Level Downstaging and Complete Pathologic Response After Preoperative Chemoradiation for Advanced Rectal Cancer Result in Decreased Recurrence and Improved Disease-Free Survival