Guggulsterone –Farnesoid X receptor interaction

Abstract

Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. The gum resin from guggul plants has been used for thousand years in Ayurveda to treat various disorders, including internal tumors, obesity, liver disorders, malignant sores and ulcers, urinary complaints, intestinal worms, leucoderma, sinuses, edema, and sudden paralytic seizures. Guggulsterone has been identified a bioactive components of this gum resin. This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism. Authors are interested to study Guggulsterone -Farnesoid X receptor interactions. Interactions were studied on Molecular Operating Environment software and the interactions of guggulsterone confirms its activity at Farnesoid X receptor.