Pathology of internal organs after infection of mice experimentally with LD50 dose of Salmonella mbandaka through the oral route

Abstract

The present was designed to study the histopathological variations of Salmonella mbandaka isolated from child on healthy animals first time in Iraq. Twenty BALB/c mice were used during the period from February to May 2017. Animals were separated into equal groups (10 mice/group) then drenched orally as the following: 1st group by lethal dose (109.5cells/ml) of Salmonella mbandaka, 2nd group with 0.5 ml PBS as control group. Post 24 hrs of infection observed 50% of animals in 1st group were dead and sacrificed lived mice after 3 days PI. The results revealed pathological changes on internal organs as: (intestine, lung, liver, spleen and kidney) manifested by sever sluphing and desquamation with cellular debris in their lumen, sever suppuration with congestion, extension destruction of liver parenchyma, sever hemorrhage of splenic parenchyma with atrophy of white pulp and sever congestion with hemosidern pigment deposition active hyperemia and congestion between renal tubules, respectively.