One pot synthesis of coumarin derivatives via pechmann condensation catalyzed by PTSA under solvent free conditions and antifungal activities of the compounds

Abstract

A rapid and efficient solvent free synthesis of coumarin derivatives by Pechmann condensation reactions of substituted phenols with β keto ester using para toluene sulphonic acid (pTSA) as a catalyst. Synthesis of coumarin derivatives has been occurred with the help of grinding techniques and comparison has been done with conventional method in which 73% H2SO4 has been used. Unique/key features of this grinding method includes short reaction time, ecofriendly, good to excellent yield, non toxic and easy to handle. These compounds were screened for their antifungal activity. These synthesized compound were characterized by IR, 1HNMR and melting point.