Modulating effects of the red alga Alsidium corallinum against potassium bromate- induced cardiotoxicity in adult mice

Abstract

Acute exposure to xenobiotics can cause cardiotoxicity. In this study, the modulatory effects of Alsidium corallinum (A. corallinum), a red alga, on the antioxidant defense mechanisms, oxidative stress and cellular redox status in the heart of mice treated with potassium bromate (KBrO3) were examined. Adult mice were divided into four groups: the first group served as control; the second group received in drinking water KBrO3 alone (0.5 g/L); the third group received both KBrO3 and A. corallinum ethanolic extract (7% of diet) and group IV received A. corallinum ethanolic extract (7% of diet). The mice exposure to KBrO3 promoted oxidative stress with a rise in lipid peroxidation and advanced oxidation protein product levels, a decrease in antioxidant enzymatic and non-enzymatic levels such as glutathione, in addition to a decline in glutathione peroxidase, superoxide dismutase and catalase activities. The biochemical results were confirmed by the histopathological findings. Co-administration of A. corallinum improved the parameters cited above. These results suggested that A. corallinum had a protective effect against KBrO3- induced toxicity in adult mice.