Evaluation of therapeutic efficacy of deferoxamine as an adjunct to rational therapy alone or in combination with vitamin C in induced endotoxemia in dogs

Abstract

The present study was conducted to evaluate the therapeutic efficacy of deferoxamine (DFX) as an adjunct to rational therapy alone or in combination with vitamin C in induced endotoxemia in a dog model in 2013 at Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad. A total of 18 adult, healthy dogs of either sex were randomly selected and divided into three equal groups viz. A, B and C. All above parameters were recorded at baseline, during septic shock, 3, 6, 12 and 24 hrs after treatment. Survival index of one week was also recorded. Group A and group B showed better survival rate of 83 % than group C (66 %). The body temperature was elevated during shock in all groups but both A and B group attained the baseline value. As also was the case with the other clinical parameters. The haemoglobin concentration, RBCs count, neutrophils and lymphocytes were at lower level during shock in all groups and attained the baseline values 24-hour post treatment. Animals of group A (treated with DFX along with antibiotic and vitamin C) as well as group B (dosed with DFX & antibiotics showed better results than group C which received DFX without antibiotics and vitamin C. It was concluded that the DFX along with antibiotics can combat the septic shock and resulted in early and better recovery.