Effects of mangiferin isolated from Mangifera indica leaves and evaluation of biologic activities of β-cyclodextrin-mangiferin complex particularly its anti-diabetic and hypolipidaemic propertieson Type 1 diabetes rat model

Abstract

Diabetes both Type 1 and Type 2 is on the increase in Indian subcontinent and both nature and nurture has to blame. In Indian rural populace the initial lower prevalence is increased and comparable to urban leading to effective management protocols (phytotherapy) optimized to rural settings. The present paper deals with the effects of mangiferin obtained from mango leaves, isolated and characterised as per existing scientific protocol (isolated mangiferin and cyclodextrin complex). Evaluation was done in respect to enzyme inhibition studies and animal experimentation models. Our findings shows enzyme inhibition studies shows to statistically significance. Further, animal experimentation studies on Type1 diabetic rat model shows mangiferin thus isolated has promising hypoglycaemic potentials in and also leading to beneficial cholesterol lowering effect, thus leading to further scientific validation in Type 1 diabetics with commercial market explore in entire diabetic scenario both Type 1 and Type 2 (existing in the market)