Evaluation of antidiarrhoeal activity of polyherbal preparation

Abstract

Antidiarrhoeal activity of polyherbal preparation containing hydro-ethanolic extracts of unripe fruits of Aegle marmelos, bark of Dalbergia sissoo and seeds of Holarrhena antidysenterica was evaluated in mice using castor oil induced diarrhea. Acute toxicity study revealed no visible signs of toxicity at 500, 1000 and 2000 mg/kg body weight in mice within and after 24 hrs. The results showed that the polyherbal preparation (400 mg/kg and 800 mg/kg) produced significant (p