Effect of Eruca sativa leaves extract on liver enzymes and lipid profile in phosphoric acid induced liver damage in male rabbits

Abstract

This study was conducted on the male rabbits to investigate the effect of Eruca sativa on the liver enzyme and lipid profile in damaged liver induced by phosphoric acid. Twenty healthy adult male rabbits were used during the period from 1 to 31 March 2017. Animals were randomly separated into four equal groups (5 rabbits / group) and treated for 30 days as the following: 1st group was a control group (C): rabbits were permitted to ad libitum provide of drinking water, 2nd group (T1): were allowed to drinking water containing 1/10 of lethal dose1530 mg /kg b.w of phosphoric acid, 3rd group (T2): were received 250 mg/ kg b.w aqueous extract of Eruca Sativa orally and 1/10 of lethal dose1530 mg /kg b.w of phosphoric acid, 4th group (T3): were received 250 mg/ kg b.w aqueous extract of Eruca Sativa orally. Fasting samples were collected after 30 days of the experimental to estimate liver enzymes and liver profile. The results revealed that oral intubation of phosphoric acid for 30 days caused hepatic dysfunction manifested by a significant elevation(P