review Open AccessTop 10% cited
ATR/CHK1 inhibitors and cancer therapy
Radiotherapy and Oncology · 2017 · Vol. 126(3) · pp. 450–464
Zhaojun Qiu(Case Western Reserve University)Nancy L. Oleinick(Case Western Reserve University)Junran Zhang✉(Case Western Reserve University)
DNA Repair MechanismsCancer-related Molecular PathwaysPARP inhibition in cancer therapyCHEK1DNA damageSynthetic lethalityCancer researchDNA repairAtaxia-telangiectasiaCancer cellG2-M DNA damage checkpointMitosisCell cycle checkpoint
MeSH terms
Poly(ADP-ribose) Polymerase InhibitorsCheckpoint Kinase 1DNA DamageHumansNeoplasmsRadiation ToleranceProtein Kinase InhibitorsMolecular Targeted TherapyAtaxia Telangiectasia Mutated Proteins
Funding
- Comprehensive Cancer Center, City of Hope
- Case Comprehensive Cancer Center, Case Western Reserve University
- School of Medicine, Case Western Reserve University
- Western University
- School of Medicine
- National Cancer Institute
Citations
372
FWCI
7.84
field-weighted impact
References
224
Percentile
98%
vs. same field & year
Citations per year
References
Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
Cell Death and Disease · 2012 · 358 citations
Causes and consequences of replication stress
Nature Cell Biology · 2013 · 2,023 citations
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
Genes & Development · 1999 · 1,367 citations
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Cancer Research · 2006 · 1,298 citations
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