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Why are there hotspot mutations in the TP53 gene in human cancers?

Cell Death and Differentiation · 2017 · Vol. 25(1) · pp. 154–160
Evan H. BaughHua Zhu KeArnold J. LevineRichard BonneauChang S. Chan
Cancer-related Molecular PathwaysCancer Genomics and DiagnosticsDNA Repair MechanismsBiologyGeneGeneticsMutantAlleleMissense mutationDNAMolecular biologyMutation

MeSH terms

Gain of Function MutationGene FrequencyHumansGenes, p53Tumor Suppressor Protein p53Mutation, Missense

Funding

  • National Institutes of Health
Citations
604
FWCI
13.19
field-weighted impact
References
23
Percentile
99%
vs. same field & year
Citations per year
References
p53 mutations in cancer
Nature Cell Biology · 2012 · 1,628 citations
Critical assessment of methods of protein structure prediction (CASP) — round x
Proteins Structure Function and Bioinformatics · 2013 · 689 citations
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Why are there hotspot mutations in the TP53 gene in human cancers? · Scinovex