Histological alterations induced due to malathion and cyclophosphamide exposure in mice

Abstract

The present study was carried out to assess the histological alterations on the hepatic tissues of mice caused due to malathion and cyclophosphamide administered orally and intra-peritoneal, respectively. For this purpose, malathion (761.5mg/kg of body weight. i.e. 50% of LD50) and cyclophosphomide (40mg/kg of body weight) were administered into Swiss albino mice before sacrificing them for histological analysis alongwith control. Malathion and cyclophosphamide exposure displayed cell injury, hepatocytes swelling, hepatocytes degeneration results in dilated central vein and sinusoids between hepatocytes with pyknotic nuclei as compared to negative control reflecting the radially arranged hepatic cords around the central vein.