Screening of isolated phytosterol from leaves of Holoptelea integrifolia (Roxb.) Planch for it’s anticonvulsant activity in experimental animals

Abstract

Objective: The majority of scientific documentation suggested prominent role of Phytosterols towards anticonvulsant activity. The main objective of the work was to evaluate anticonvu ant activity of Holoptelea integrifolia isolated Phytosterol (HIIP) from petroleum ether extract (PEHI) of leaves of Holoptelea integrifolia (Roxb) Planch Methods: The anticonvulsant activity of different doses of HIIP (10 and 30 mg/kg-p.o.) was evaluated using Pentylenetetrazole (PTZ) induced convulsions in mice and lithium-pilocarpine induced status epilepticus in rats. Results: HIIP 30 mg/kg was more potent than HIIP 10 mg/kg for showing anticonvulsant activity. Conclusions: The results indicate that HIIP shows anticonvulsant activity which was dose dependent.