article Open AccessTop 1% cited
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Critical Care · 2017 · Vol. 21(1) · pp. 234–234
Akram Khan✉(Oregon Health & Science University)Cody Benthin(Oregon Health & Science University)Brian Zeno(Riverside Methodist Hospital)Timothy E. Albertson(University of California, Davis)John H. Boyd(St. Paul's Hospital)Jason D. Christie(University of Pennsylvania)Richard Hall(Nova Scotia Health Authority)Germain Poirier(Hôpital Charles-Le Moyne)Juan J. Ronco(Vancouver General Hospital)Mark Tidswell(Baystate Medical Center)Kelly Hardes(GlaxoSmithKline (United Kingdom))William Powley(GlaxoSmithKline (United Kingdom))Tracey J. Wright(GlaxoSmithKline (United Kingdom))Sarah Siederer(GlaxoSmithKline (United Kingdom))David Fairman(GlaxoSmithKline (United Kingdom))David A. Lipson(GlaxoSmithKline (United States))Andrew I. Bayliffe(GlaxoSmithKline (United Kingdom))Aili L. Lazaar(GlaxoSmithKline (United States))
Abstract
ClinicalTrials.gov, NCT01597635 . Registered on 26 January 2012.
Renin-Angiotensin System StudiesReceptor Mechanisms and SignalingHeart Failure Treatment and ManagementMedicineARDSPlaceboAngiotensin IIDosingAngiotensin-converting enzyme 2Renin–angiotensin systemPharmacodynamicsAngiotensin-converting enzymeInternal medicine
MeSH terms
Angiotensin-Converting Enzyme 2AdultAgedBlood Gas AnalysisDouble-Blind MethodFemaleHumansIntensive Care UnitsPeptidyl-Dipeptidase AMaleMiddle AgedNorth AmericaPilot ProjectsPlacebosRespiratory Distress Syndrome
Funding
- GlaxoSmithKline
- University of Pennsylvania
- Northwestern University
- Wake Forest University
- Tulane University
- Thomas Jefferson University
- McGill University
- University of South Carolina
- McGill University Health Centre
- University of California, Davis
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
Citations
626
FWCI
57.27
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
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References
Physiology of Local Renin-Angiotensin Systems
Physiological Reviews · 2006 · 1,727 citations
Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system
Journal of Endocrinology · 2012 · 522 citations
The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
American Journal of Respiratory and Critical Care Medicine · 1994 · 6,745 citations
World Medical Association Declaration of Helsinki
JAMA · 2013 · 28,008 citations
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