Multimodal approach to predict ovarian malignancy prior to laparoscopy

Abstract

Objective: To assess the performance of Ca-125, transvaginal sonography and RMI in prediction of ovarian cancer. Methods: This is a prospective study of 60 women conducted at Dr. D.Y Patil Medical College and Hospital, Pimpri. Patients underwent Serum Ca-125 level, transvaginal sonography and risk of malignancy index (RMI) was calculated as per formula devised by Jacobs et al into high risk, moderate risk and low risk. Results: The mean age of patients detected as malignant was 49.33 years. Using multimodal approach, achieved sensitivity of 100%, 33.33% and 66.67% and specificity of 52.94%, 58.82% and 94.12% in low, moderate and high risk group as per RMI categorization. Conclusion: Multimodal approach using Ca-125, TVS and RMI calculation helps in predicting women with ovarian cancer prior to laparoscopy or laparotomy. The methodology is simple and can be used in gynecology clinics and less-specialised centres.