Acute toxicity of ibuprofen on selected biochemical and oxidative stress parameters of liver in Clarias gariepinus Juveniles (Burchell, 1822)

Abstract

The present study evaluated the acute toxicity of Ibuprofen (IBU) on lipid peroxidation, antioxidant enzyme system and biochemical parameters of Clarias gariepinus juveniles. The 96 h LC50 of IBU was 0.38 mg·L-1, in a semi static system with significant difference (p< 0.05) in LC10-90 values obtained for different durations of exposure. Catalytic activities of glutathione reductase (GR), Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and lipid peroxidation (LPO) were evaluated. Biochemical parameters such as serum glucose, protein, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also measured. LPO (130.62%), SOD (76.95%), CAT (69.09%), GR (47.04%) and the liver function parameters ALP (37.70%), AST (35.55%) and ALT (69.45%) were all significantly (p