In-vitro thrombolytic activity and phytochemical evaluation of leaf extracts of four medicinal plants of Asteraceae family

Abstract

The present study was designed to investigate the comparative study of the thrombolytic activity and phytochemical analysis of the methanolic extract of leaves of Wedelia chinensis Osbeck. Merr., Eclipta alba (L) Hassk., Emilia sonchifolia (L.) DC. and Spilanthes paniculata Wall. (All of which have the same family-asteraceae) were determined. From our study we also found that Wedelia chinensis Osbeck. Merr., Emilia sonchifolia (L.) DC., Eclipta alba (L) Hassk. and Spilanthes paniculata Wall. Showed 24.48%, 28.71%, 15.19% and 42.77% clot lysis activity respectively and they showed significant % of clot lysis effect with reference of Streptokinase (71.43%) and water (2.96%). The phytochemical analysis showed the presence of different phytochemicals of different fractions of solvents. It is concluded that the in-vitro thrombolytic activity showed by the plants were due to the presence of these phytochemicals. Further studies are highly needed for further drug development.