Phytochemical analysis and bioactivity prediction of compounds in methanolic extracts of Curculigo orchioides Gaertn.

Abstract

Curculigo orchioides Gaertn. a medicinal herb with diverse pharmacological activities has been considered as a wonder crop for people working in the herbal pharmaceuticals. Preliminary screening for the presence of phytochemicals in rhizome and leaf extracts of C. orchioides was carried out through qualitative tests. GC-MS analysis of methanolic extracts of leaves and rhizome revealed the presence of several compounds and were interpreted based on the reported compounds in NIST-Wiley library. PASS prediction analysis revealed the pharmacological activities of phytoconstituents in the extracts of C. orchioides. In leaf extracts, the compound 2-Myristynoyl pantetheine covered the max peak area of 32.72%. Further in leaf extracts, 4-Acetyloxyimino-6,6-dimethyl-3-methylsulfanyl-4,5,6,7-tetrahydro benzo [c] thiophene -1 carboxylic acid methyl ester was also found to possess biological role in treatment of Alzheimer's disease, neurodegenerative disease and cognition disorders. In rhizome, the compound 2,7-Diphenyl-1,6-dioxopyridazino [4,5:2',3']pyrrolo[4',5'-d] pyridazine covered maximum peak area (18.36%) which has predicted biological activity as an antiepileptic, for treating renal disease, heart failure and Alzheimer's disease.