Beneficial effect of hydroethanolic extract of Ocimum basilicum L on enzymic and non enzymic antioxidant in depression induced rats

Abstract

The antidepressant activity of Ocimum basilicum L was studied by administrating plant low dose (250 mg/Kg of bw) and high dose (500 mg/kg of bw) in depression induced rats. Imipramine (30 mg/Kg of bw) was selected as the standard drug which showed significant antidepressant activity. Hydroethanolic extract was orally administered to experimental rats for 14 days after the induction of depression. The status of depression was confirmed by using Forced Swimming Test (FST) in experimental rats. Enzymic and non- enzymic antioxidant level were analysed in control and experimental groups. The results showed that the extract decreased immobility time after the treatment. The level of enzymic and non - enzymic antioxidants were increased significantly levels in the brain tissues of experimental groups. Thus it may be concluded that Ocimum basilicum showed high propensity to improve the antioxidant status in rats. Hence, the antioxidant effect may be the cardinal mechanism of Ocimum basilicum in antidepressant activity. Further studies may elucidate the possibility of the commercial use of Ocimum basilicum for the benefit of patients suffering from depression.