Pharmacological evaluation of traditional claims of Jharkhand region: Using seeds of Wrightia tinctoria, a adulterant of kurchi in hyperglycemia and hyperlipidemia

Abstract

The seeds of Wrightia tinctoria (Roxb) R.Br., is known as adulterant of kurchi seed. W. tinctoria has been widely used for treatment of various medical complications in traditional system of medicine in north and central India. Commonly Wrightia tinctoria R. Br. Known as sweet indra-jao, dudhi, Pala Indigo Plant, Paalai plant. The present investigation deals with Hyperglycemic and Hyperlipidemic effect of ethanolic extract of seed of W. Tinctoria in alloxan induced diabetic albino rats. This claim was based on tradition practice followed by some traditional healers of Jharkhand region for treatment of diabetes and management of high cholesterol level. In this study diabetic rats were treated with extracts of Wrightia tinctoria (WT) 200 & 400 mg/kg body weight in (1% CMC) for 21 days. The results were compared with that of the standard drug glibenclamide. Blood glucose levels were estimated and serum total cholesterol (TCH), Triglycerides (TG) and High density lipoprotein (HDL) levels were also evaluated in normal and alloxan induced diabetic rats. Both the extracts (WT1 and WT2) significantly lowered blood glucose level. The WT1 and WT2 extracts also produced a significant decrease in the serum levels of total cholesterol (TCH) and (TG) triglycerides and significant increase in (HDL) high density lipoprotein levels.