Assessment of neuropharmacological activities of Borassus flabellifer L. roots

Abstract

In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for the safety along with neuropharmacological activity by using OECD guidelines, y-maze, elevated plus-maze and open field test respectively. Mortality, sign of any toxicity or behavioral changes were not noticed up to the dose as high as 4000mg/kg. Moreover, in y-maze test, MBF 200 mg/kg and MBF 400 mg/kg exhibited anti-depressive and depressive activities. Again, every extract including both lower and higher doses elicited depressive, anti- depressive and anxiolytic activities in elevated plus maze test. Later, in open field test, significant (p