A highly efficient synthesis of 2-chloro-3-formyl-8-methyl quinoline: Vilsmeier-haack reagent

Abstract

For the synthesis of substituted i.e. 2-chloro-3-formyl-8-methyl Quinoline    an  highly efficient, simple  and convenient method through Vilsmeier-Haack reagent has been developed in high yields, less raw material, and less time requiring for completion of reaction.In the present research work the substituted quinoline and acetanilide are synthesized through Vilsmeier reaction has been reported to the substitution reaction by substituted acetanilide bearing electron donating group at ortho position and electron attracting group at ortho position are investigated and it is good in all case. Further, the nucleophilic substitution reaction of the substituted quinoline is also investigated. Similarly in quinoline the –CHO (formyl) group is subjected for further transformation of formyl group in to (4’-NO2 nitro group, 3’N-NH-C6H5) 3’-CH3 group and 3’-N-benzylidene group.