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Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Nature Neuroscience · 2017 · Vol. 20(8) · pp. 1172–1179

Ken Y. Chan✉(California Institute of Technology)Min Jee Jang(California Institute of Technology)Bryan B. Yoo(California Institute of Technology)Alon Greenbaum(California Institute of Technology)Namita Ravi(California Institute of Technology)Wei‐Li Wu(California Institute of Technology)Luís Sánchez-Guardado(California Institute of Technology)Carlos Lois(California Institute of Technology)Sarkis K. Mazmanian(California Institute of Technology)Benjamin E. Deverman(California Institute of Technology)Viviana Gradinaru(California Institute of Technology)

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Virus-based gene therapy research CRISPR and Genetic Engineering RNA Interference and Gene DeliveryTransduction (biophysics)TransgeneBiologyGene deliveryDorsal root ganglionNeuroscienceCentral nervous systemGenetic enhancementAdeno-associated virusCell type

MeSH terms

DependovirusAnimalsGanglia, SpinalGenetic VectorsMice, TransgenicNeuronsTransduction, GeneticGenetic TherapyPeripheral Nervous SystemGene Transfer Techniques

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References

A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging

eLife · 2016 · 698 citations

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