Pharmacognostical, Phytochemical and Pharmacological Evaluation for the Antiulcer Activity of Polyherbal Suspension

Abstract

Objective: From the past few years there is increasing research interest on the natural compounds, due to their wide variety of pharmacological activities. The main aim of the present study was to conduct the evaluation of the Poly herbal suspension (PHS) which includes the preliminary phytochemical screening, standardisation and experimental antiulcer activity. Methods: In this study we conduct the phytochemical screening, standardisation using the high performance thin layer chromatography (HPTLC) & infra-red spectroscopy (IR). Also, the PHS was evaluated for the acute toxicity and antiulcer activity at 400 mg/kg and 800 mg/kg in adult albino wistar rats induced by the ethanol (1ml/kg), indomethacin (40mg/kg) and aspirin (150mg/kg) ulcer models. Results: After phytochemical screening, the PHS showed the presence of the terpenoids, flavonoids and tannins which produces antiulcer activity. The therapeutic efficacy achieved at both dose levels of the PHS when compared with the standard sucralfate (100mg/kg) showed a significant (P