Evaluation of anti-inflammatory activity of Aptenia cordifolia leaves extract in wistar albino rats

Abstract

The present study evaluated the anti-inflammatory activity of Aptenia cordifolia ethanolic leaves extract in wistar albino rats. The rats were divided into four groups of six animals each. Group I served as the negative control and received 10 mL/kg of distilled water orally. Group II was the positive control and received the reference drug diclofenac sodium 20mg/kg. Group III and IV received 150 mg/kg and 300mg/kg of ethanolic extracts of A. Cordifolia by oral route respectively. A 0.1 ml of freshly prepared egg albumin was injected into the sub plantar tissue of the right hind paw of the rats to induce inflammation. A micrometer screw gauge was used to measure the size of the rat’s paw before and after administration of inflammatory agent. The ethanolic leaf extract of A. cordifolia showed anti-inflammatory activity against egg albumin induced oedema. A. Cordifolia leaf extract has ant-inflammatory properties and can therefore be used against inflammation