Evaluation of serum and salivary sialic acid and nitric oxide levels in chronic periodontitis patients

Abstract

Background: Chronic gingivitis and periodontitis are inflamma­tory diseases. Sialic acid occupies the interface between the host and pathogenic microorganisms. Nitric oxide has been linked to the etiopathogenesis of periodontal disease and is expressed in salivary glands as well as in their product. Hence this study has been designed to compare the evaluation of serum and salivary nitric oxide and sialic acid in chronic periodontitis patients Aim: To evaluate the serum sialic acid and nitric oxide level in periodontally healthy and chronic periodontitis subjects. To evaluate the salivary sialic acid and nitric oxide level in periodontally healthy and chronic periodontitis subjects. To correlate the levels of serum and salivary sialic acid and nitric oxide with disease severity Material and Methods: 40 subjects will be selected and will be divided into two groups. Group I – 20 subjects who are systemically healthy with healthy gingiva (Control group). Group II – 20 subjects who are systemically healthy with chronic periodontitis. (Periodontitis group). Clinical examination was done and the following parameters were assessed: Gingival index, Clinical Attachment Loss.