Phytochemical and Biological Study of the Aerial Parts of Chrozophora oblongifolia (Delile) Spreng. (Euphorbiaceae)

Abstract

Phytochemical investigation of the aerial parts of Chrozophora oblongifolia afforded four compounds isolated for first time from the species including: 1-octacosanol (1), lupeol (2), para-hydroxybenzoic acid (3) and methyl gallate (4), in addition to previously isolated compound, amentoflavone (5), were isolated from methylene chloride and ethyl acetate subfractions of methanolic extract of C. oblongifolia aerial parts. Their structures were elucidated on the basis of different physical, chemical and spectral techniques. The total extract and its subfractions showed variable in vitro antiviral activities against Herps Simplex Virus (HSV-1), where the methanol subfraction showed highest antiviral activity (68.1%) and n-hexane subfraction showed lowest antiviral activity (25.1%). Total extract and methanol subfraction showed significant wound healing activity on excision wound model in albino rats.