Adaptogenic activity of Plumbago zeylanica Linn and Plumbago rosea : An experimental study using swiss albino mice by swimming endurance test

Abstract

The present study was designed to evaluate the adaptogenic activity of hydroethanolic extract of roots of Plumbago zeylanica and Plumbago rosea on Swiss Albino mice using swimming endurance test. The Plumbago zeylanica (Linn.) and Plumbago rosea (Linn.) extract were found to be safe 2000 mg/kg of body weight. Therefore 1/5 and 1/10th cut off dose for Plumbago zeylanica (Linn.) and Plumbago rosea (Linn.) extract are 100 and 200 mg/kg were selected for present study (OECD 2000). The swimming time of mice was 289.7 s (S-100), 363.0 s(S-200) and 312.8 s (S-100), 396.7 s (S-200) for Plumbago zeylanica extract S and Plumbago roseaextract a respectively and the same was 224.3 s and 478.0 s for control and standard (Korean Ginseng).The results of phytochemical screening reveals that the major constituents of Chitrak extract are flavonoids, phenolics compound, alkaloids, anthraquinones, glycosides and naphthoquinone compounds which may be responsible for the antioxidant, memory enhancement and adaptogenic activity. Adaptogens have not only specific therapeutic effects in some stress induced and stress related disorders, but will also have an impact on the quality of life of patients.