article Open AccessTop 1% cited
Family history and risk of breast cancer: an analysis accounting for family structure
Breast Cancer Research and Treatment · 2017 · Vol. 165(1) · pp. 193–200
Hannah R Brewer✉(Institute of Cancer Research)Michael E. Jones(Institute of Cancer Research)Minouk J. Schoemaker(Institute of Cancer Research)Alan Ashworth(UCSF Helen Diller Family Comprehensive Cancer Center)Anthony J. Swerdlow(Institute of Cancer Research)
Abstract
A family history score based on expected as well as observed breast cancers in a family can give greater risk discrimination on breast cancer incidence than conventional parameters based solely on cases in affected relatives. Our modeling suggests that a yet stronger predictor of risk might be a combination of this score and age at diagnosis in relatives.
BRCA gene mutations in cancerGlobal Cancer Incidence and ScreeningCancer Genomics and DiagnosticsBreast cancerFamily historyMedicineRisk factorPopulationIncidence (geometry)CancerGynecologyDemographyOncology
MeSH terms
AdolescentAdultAge FactorsAgedAged, 80 and overBreast NeoplasmsFamily CharacteristicsFemaleUnited KingdomHumansMedical History TakingMiddle AgedPedigreeProspective StudiesRisk Factors
Funding
- Breast Cancer Now
- Cancer Research UK
- National Institute for Health and Care Research
- Institute of Cancer Research
Citations
302
FWCI
16.29
field-weighted impact
References
51
Percentile
99%
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Citations per year
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