Preventive effect of phloroglucinol against adverse protein alterations in streptozotocin induced diabetic rats

Abstract

Diabetes mellitus is often associated with long term vascular complications including neuropathy and nephropathy. Long lasting diabetic complications are known to cause abnormalities in the synthesis and transport of protein with the increase the net protein loss in the body. The aim of the present study was to evaluate the protective effect of phloroglucinol (150,200,250 mg/kg; per oral) on the protein loss in diabetic rats. Diabetes was induced by a single dose of STZ (streptozotocin) (55mg/kg i.p.) and was treated with phloroglucinol for 8 weeks. Phloroglucinol treated animals showed a significant increase in protein level as evidence from increase serum albumin and total protein (kidney and sciatic nerve homogenate) along with the reduction in serum glucose and creatinine. Treatment with phloroglucinol for 8 weeks significantly improves the biochemical deficit in a dose dependent manner. The study demonstrated the effectiveness of phloroglucinol in attenuation of protein loss in diabetic complications.