article Open AccessTop 1% cited
Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression
Hepatology · 2017 · Vol. 66(4) · pp. 1151–1164
Dan Han(Zhejiang University)Jiangxue Li(Zhejiang University)Huamin Wang(Chinese Academy of Medical Sciences & Peking Union Medical College)Xiaoping Su(Second Military Medical University)Jin Hou(Second Military Medical University)Yan Gu(Second Military Medical University)Cheng Qian(Second Military Medical University)Yun Lin(Second Military Medical University)Xiang Liu(Second Military Medical University)Mingyan Huang(Second Military Medical University)Nan Li(Second Military Medical University)Weiping Zhou(Eastern Hepatobiliary Surgery Hospital)Yizhi Yu✉(Second Military Medical University)Xuetao Cao✉(Second Military Medical University)
Abstract
circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients. (Hepatology 2017;66:1151-1164).
Circular RNAs in diseasesMicroRNA in disease regulationGene silencingmicroRNABiologyCancer researchCompeting endogenous RNACircular RNASmall interfering RNALong non-coding RNACancerRNA interference
MeSH terms
AnimalsCarcinoma, HepatocellularHumansLiver Neoplasms, ExperimentalMaleMice, NudePrognosisBiomarkers, TumorMicroRNAsHep G2 Cells
Funding
- National Natural Science Foundation of China
Citations
1,338
FWCI
80.71
field-weighted impact
References
43
Percentile
100%
vs. same field & year
Citations per year
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