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Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Annals of Neurology · 2017 · Vol. 81(6) · pp. 857–870

Giulio Disanto(Laboratory for Biomedical Neurosciences)Christian Barro(University Hospital of Basel)Pascal Benkert(University Hospital of Basel)Yvonne Naegelin(University of Basel)Sabine Schädelin(University of Basel)Antonella Giardiello(Laboratory for Biomedical Neurosciences)Chiara Zecca(Laboratory for Biomedical Neurosciences)Kaj Blennow(University of Gothenburg)Henrik Zetterberg(University College London)David Leppert(University Hospital of Basel)Ludwig Kappos(University Hospital of Basel)Claudio Gobbi(Laboratory for Biomedical Neurosciences)Jens Kühle✉(University Hospital of Basel)the Swiss Multiple Sclerosis Cohort Study Group

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Abstract

These results support the value of sNfL as a sensitive and clinically meaningful blood biomarker to monitor tissue damage and the effects of therapies in MS. Ann Neurol 2017;81:857-870.

Multiple Sclerosis Research Studies Neurogenesis and neuroplasticity mechanisms Circadian rhythm and melatoninMultiple sclerosisBiomarkerNeurofilamentMedicineNeurosciencePathologyImmunologyPsychologyBiologyImmunohistochemistry

MeSH terms

AdultAgedBiological AssayBrainCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple SclerosisPilot ProjectsRecurrenceSpinal CordBiomarkers