article
Synthesis, characterization and biological evaluation of novel 3-amino-1-(phenyl) benzo [f] quinoline-3-carbonitrile derivatives
International Journal of Chemical Studies · 2016 · Vol. 4(5) · pp. 05–09
Abstract
A series of 3-amino-1(phenyl) benzo[f]quinoline-3-carbonitrile derivatives were synthesized by one pot Multi Component Reactions (MCRs) with different aromatic aldehyde, 2-Napthylamine and malononitrile using iodine and l-proline as catalyst. The main advantages for present high efficient method are short reaction time and higher yield. All of the synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, Mass spectroscopy. Antibacterial and antifungal potential of the synthesized derivatives was studied against various bacterial and fungal strains respectively. Few derivatives were found to exhibit good antimicrobial activity.
Synthesis and biological activityMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applicationsMalononitrileQuinolineChemistryAldehydeYield (engineering)AntimicrobialCatalysisCarbon-13 NMROrganic chemistryAntifungal
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