The action of a natural polyphenol on diabetic animals developing neuro-behavioral and cognitive disorders

Abstract

The aim of the present research was to evaluate the effects of a natural polyphenol, the Hesperidin, on induced diabetic wistar rats, on their neuro-behavioral alterations and movement functions. Four series of rats were used in the assays representing the control, and the treated series (Hesperidin, Streptozotocin and Hesperidin with Streptozotocin). After inducing the diabetes, the animals were exposed individually to the labyrinth in cross heightened test for a period of 5mn. Results of The test showed a slowing down in the movements, flexibility and a high level of anxiety on the diabetic rats. Thus, our results confirm the capacity of hesperidin as an antioxidant to reduce and to correct neurobehavioral and locomotion disorders related to diabetes and its complications by neutralizing free radicals generated by this metabolic disease.