Effects of ethanolic extracts of Cola millenii K. Schum seed on biochemical and toxicological indices of male wistar albino rats

Abstract

Cola millenii is a medicinal plant believed to have many agents acting in different ways for the health benefits of humans. This study investigated the acute toxicity, phytochemicals content and the effects on haematological indices, lipid profile, and biomarkers of cardiac and prostate dysfunction. Twenty eight (28) adult male Wistar albino rats weighing 151-195 g were used in four groups of six animals. Group 1 (control) received 0.34 ml of 20% Tween® 80 as placebo, groups 2, 3 and 4, received intraperitoneal injection of 150, 300 and 450 mg/kg body weight of the extract respectively for seven days. The result indicates the presence of alkaloids, terpenes, saponins and cardiac glycosides. Intraperitoneal LD50 was 2645.75 mg/kg body weight. There was significant (p