Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental animals

Abstract

The present study aimed to evaluate the effect of 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) on Phenylbutazone induced chronic gastric damage in experimental rats. Animals were induced for gastric ulcer with Phenylbutazone (100mg/kg bodyweight) and treated orally with ARE (250 and 500 mg/kg bodyweight). The effective dose i.e. 500 mg/kg elicited a maximum reduction in lesion index. The gastroprotective effect of ARE was assessed from the levels of different physicochemical parameters. The levels of DNA, protein bound carbohydrate complexes-hexose, hexoseamine, sialic acid, fucose in gastric juice were assessed. A significant reduction (p