Evaluation of antiulcer activity of roots of Acacia catechu Willd. (Mimosoideae)

Abstract

The present study was conducted to evaluate the antiulcer activity of 95% ethanolic and aqueous extract of roots of acacia catechu willd. Acacia catechu willd. (Mimosoideae) is a deciduous, thorny tree of genus Acacia which grows upto 15 m height; widely distributed throughout India and used traditionally for the treatment of asthma, bronchitis, pain in chest, ulceration, wound healing, sores in mouth, colic, vitiligo, cancer, sore throats, diarrhea, antiviral, spasmolytic, antifungal and hypoglycemic activity. Previous investigations of some other Acacia species revealed that the genus acacia be a rich source of flavonoids and tannins, which exhibited broad activities including antioxidant, antipyretic, antileprosy, antidiarrheal, antimicrobial, antibacterial, antifertility, anticancer, immunomodulatory, chronic renal failure, hepatoprotective, hypotensive, hypoglycemic & wound healing. Antiulcerogenic activity of this drug has been evaluated using aspirin + pylorus ligated ulcer model, ethanol induced ulcer model and NSAID’s induced ulcer model. Both extract of roots of Acacia catechu Willd found to possess antiulcer activity and it had observed that activity increases as the dose of extracts increases.