Antioxidant and antimicrobial activities of flower and bark extract of Swietenia mahagoni (L.) Jacq.

Abstract

Different Kupchan partitionates of flower and bark extracts of Swietenia mahagoni (L.) Jacq. were subjected to assays for determination of antioxidant activities by evaluating free radical scavenging activity and total phenolic content and also antimicrobial activity by using bacteria and fungi. In the first finding, aqueous soluble fraction of both extracts showed the highest free radical scavenging activity having IC50 values of 1.18±0.31 I¼g/ml and 7.60±0.54 I¼g/ml, respectively while reference standards tert-butyl-1-hydroxytoluene and ascorbic acid gave 27.50±0.95 I¼g/ml and 5.80±1.03 I¼g/ml, respectively. In total phenolic content assay, the highest amount of phenolic compounds was found in aqueous soluble fraction in both extracts (1.80±0.56 and 1.07±0.45 mg of gallic acid equivalent/gm of extractives, respectively). In antimicrobial screening, different fractions were applied to bacteria and fungi, among which, both the methanol extracts showed moderate activity with maximum activity against Pseudomonas aeruginosa having zone of inhibition 18±0.44 mm and 25±0.29 mm, respectively.