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Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

BMJ Open · 2017 · Vol. 7(2) · pp. e013537–e013537

Kerry Avery✉(University of Bristol)Paula Williamson(University of Liverpool)Carrol Gamble(University of Liverpool)Elaine O’Connell Francischetto(University of Bristol)Chris Metcalfe(University of Bristol)Peter Davidson(National Institute for Health Research)Hywel C Williams(Nottingham University Hospitals NHS Trust)Jane Blazeby(University Hospitals Bristol NHS Foundation Trust)

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Abstract

Systematic and transparent reporting of the design, results and evaluation of internal pilot trials in the literature should be encouraged in order to facilitate understanding in the research community and to inform future trials.

Health Systems, Economic Evaluations, Quality of Life Meta-analysis and systematic reviews Health Policy Implementation ScienceMedicineMedical physics

MeSH terms

AttitudeClinical ProtocolsDecision MakingHumansPilot ProjectsResearch DesignResearch PersonnelRandomized Controlled Trials as TopicOutcome Assessment, Health CarePatient SelectionGuideline AdherenceClinical Trials Data Monitoring CommitteesResearch Report