Comparative Prediction of binding site of Organophosphorus, Carbamate and Synthetic pyrethroid Pesticides on Human Cyclin-dependent Protein kinases Cdk2 and Cdk4

Abstract

The pesticides are used for plant protection and control pests. They enter into the cell cycle thereby affecting important regulatory elements. The impact of organophosphorus, carbamate and synthetic pyrethroid pesticides on cyclin-dependent protein kinases Cdk2 and Cdk4 in human being have been evaluated in the present study. The binding affinity of selected pesticides with human Cdk2 and Cdk4 [using Molegro Virtual Docker (MVD)] are in decreasing order i.e. organophosphorus > carbamate > Synthetic pyrethroid. Many of these alterations affect the cyclin-dependent kinases (CDKs) and their regulation interfere in the cell cycle and cause irregular cell division which may lead to carcinogenesis in human beings.