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MECHANISMS IN ENDOCRINOLOGY: Diabetes mellitus, a state of low bone turnover – a systematic review and meta-analysis
European Journal of Endocrinology · 2017 · Vol. 176(3) · pp. R137–R157
Katrine Hygum✉(Aarhus University Hospital)Jakob Starup‐Linde(Aarhus University Hospital)Torben Harsløf(Aarhus University Hospital)Peter Vestergaard(Aalborg University Hospital)Bente Langdahl(Aarhus University Hospital)
Abstract
Markers of both bone formation and bone resorption are decreased in patients with diabetes. This suggests that diabetes mellitus is a state of low bone turnover, which in turn may lead to more fragile bone. Altered levels of sclerostin and osteoprotegerin may be responsible for this.
Bone health and osteoporosis researchBone health and treatmentsBone Metabolism and DiseasesInternal medicineEndocrinologyMedicineMeta-analysisDiabetes mellitusBone remodelingType 2 Diabetes Mellitus
MeSH terms
Tartrate-Resistant Acid PhosphataseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Genetic MarkersHumansPeptide FragmentsProcollagenBiomarkersOsteocalcinCase-Control StudiesBone RemodelingBone Morphogenetic ProteinsCollagen Type IIAdaptor Proteins, Signal TransducingOsteoprotegerin
Citations
313
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25.35
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109
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References
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American Journal of Epidemiology · 2007 · 1,202 citations
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