Anti-Oxidant and hepatoprotective activities of ethanolic root extract of Bauhinia variegata Linn

Abstract

To study the hepatoprotective activity of BVEE. In-vitro Antioxidant Studies was carried out by using Nitric oxide scavenging activity method and DPPH radical scavenging activity method. Albino wistar rats of either sex weighing 150-200g were divided into five groups. Liver injury was produced by CCL4 1 ml/kg/d dissolved in olive oil (1:1) orally. Silymarin (100mg/kg) orally was used as standard drug. Test groups received BVEE in the doses of 200,400 mg/kg/day orally along with CCl4. Treatment was given to all the groups daily for 5 days. The hepatoprotective effect of BVEE was evaluated by assessment of biochemical parameters AST, ALT, ALP and Level of total protein Histopathological examination of the liver was also done. BVEE (200mg/kg and 400 mg/kg) exhibited highly significant reduction (p