Highly methoxylated flavonoids and the anti-eczematous activity of Rhamnus disperma roots

Abstract

Chromatographic investigation of Rhamnus disperma roots was resulted in the isolation of two highly methoxylated flavonoids; myricetin 3,6,7,3`,4`,5`-O-hexamethyl ether (1) and myricetin 3,6,7,4`,5`-O-pentamethyl ether (2) together with quercetin 3-O-methyl ether (3) and quercetin (4). The structures of these compounds were assigned on the basis of spectroscopic data. Occurrence of compounds 1 and 2 in Genus Rhamnus are reported here for the first time. The alcoholic extract of Rhamnus disperma roots showed significant anti-eczematic activity against induced eczema in mice.